Convenient synthesis of collagen-related tripeptides for segment condensation
نویسندگان
چکیده
منابع مشابه
Convenient synthesis of collagen-related tripeptides for segment condensation.
Chromatography is a common step in the solution-phase synthesis of typical peptides, as well as peptide fragments for subsequent coupling on a solid support. Combining known reagents that form readily separable byproducts is shown to eliminate this step, which wastes time and other resources. Specifically, activating carboxyl groups with isobutyl chloroformate or as pentafluorophenyl esters and...
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The structures of four polyhexapeptide collagen models have been investigated by X-ray diffraction. It has been found that (Gly-Ala-Pro-Gly-Pro-Pro),, (Gly-Pro-Ala-Gly-Pro-Pro),, (Gly-Ala-Pro-Gly-Pro-Ala), and (Gly-Ala-Ala-GlyPro-Pro),, all show typical collagen-like diffraction patterns, although there is some variation among the polymers in modes of lateral packing and in axial repeat distanc...
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ژورنال
عنوان ژورنال: Biopolymers
سال: 2015
ISSN: 0006-3525
DOI: 10.1002/bip.22700