Convenient synthesis of collagen-related tripeptides for segment condensation

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Convenient synthesis of collagen-related tripeptides for segment condensation.

Chromatography is a common step in the solution-phase synthesis of typical peptides, as well as peptide fragments for subsequent coupling on a solid support. Combining known reagents that form readily separable byproducts is shown to eliminate this step, which wastes time and other resources. Specifically, activating carboxyl groups with isobutyl chloroformate or as pentafluorophenyl esters and...

متن کامل

Polymers of Tripeptides as Collagen Models

The structures of four polyhexapeptide collagen models have been investigated by X-ray diffraction. It has been found that (Gly-Ala-Pro-Gly-Pro-Pro),, (Gly-Pro-Ala-Gly-Pro-Pro),, (Gly-Ala-Pro-Gly-Pro-Ala), and (Gly-Ala-Ala-GlyPro-Pro),, all show typical collagen-like diffraction patterns, although there is some variation among the polymers in modes of lateral packing and in axial repeat distanc...

متن کامل

A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)

Radioiodinated meta iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [123/131I]MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a...

متن کامل

A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)

Radioiodinated meta iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [123/131I]MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a...

متن کامل

O-acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation.

We report the establishment of the O-acyl isopeptide method-based racemization-free segment condensation reaction toward future chemical protein synthesis. Peptide segments containing C-terminal O-acyl Ser/Thr residues were successfully synthesized by use of a lower nucleophilic base cocktail for Fmoc removal, and then coupled to an amino group of a peptide-resin without side reactions or epime...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biopolymers

سال: 2015

ISSN: 0006-3525

DOI: 10.1002/bip.22700